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The Molecular Relationship - Kindle edition by J J Dewey. Download it once and read it on your Kindle device, PC, phones or tablets. Use features like. Jul 21, The molecular relationship between antigenic domains and epitopes on hCG. Berger P(1), Lapthorn AJ(2). Author information: (1)Institute for.
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You have access to this article. Please wait while we load your content Something went wrong. Electronic address: peter. Antigenic domains are defined to contain a limited number of neighboring epitopes recognized by antibodies Abs but their molecular relationship remains rather elusive.
We thoroughly analyzed the antigenic surface of the important pregnancy and tumor marker human chorionic gonadotropin hCG , a cystine knot ck growth factor, and set antigenic domains and epitopes in molecular relationships to each other. Variability in Ab binding modes to the contact aa residues are responsible for the variation in affinity and intra- and inter-species specificity, e.
The structural disorder is essential to the oncogenic function [ 4 , 23 ]. Please review our Terms and Conditions of Use and check box below to share full-text version of article. Cited by. The spliceosome is a ribozyme that uses a two-metal ion mechanism for catalysis [ 59 ]. There are very few articles that investigate the thermodynamic formation of two-component molecular crystals.
Each genetically distinct fragment antigen binding Fab defines its own epitope.